Morphological Structures and Drug Release Effect of Multiple Electrospun Nanofibre Membrane Systems Based on PLA, PCL, and PCL/Magnetic Nanoparticle Composites

Biopolymers are good carrier materials in relation to efficient release sustainability for encapsulated drugs. In particular, electrospun polymer/composite fibre membranes can offer greater benefits owing their competitive features as well large specific surface areas. this study, multiple nanofibre membrane systems were utilised including different material such poly(lactic acid) (PLA), poly(?-caprolactone) (PCL), and PCL/magnetic nanoparticle (MP) composites loaded with tetracycline hydrochloride (TCH) a therapeutic compound potential use drug delivery applications. Such nanofibres investigated understand how composite constituents could tailor morphology control biodegradation effect of PCL nanofibers on long term systems. Fibre diameter appeared be decreased considerably the addition TCH drug. It was also evident that average reduced when embedding MPs enhancement solution conductivity. The encapsulation found effective, evidenced by Fourier transform infrared (FTIR) spectra. Thermogravimetric analysis (TGA) data revealed no significant change thermal stability inclusion MPs. However, PLA delayed degradation. Glass transition temperature ( T g ) melting id="M2"> m TCH. degree crystallinity id="M3"> X c diminished incorporated Additional PLA, PCL, PCL/MP nanocomposites resulted moderate decrease id="M4"> . might dispersed an amorphous state within membranes. Over short-term periods, it clearly seen from higher opposed PLC/MP counterparts. On contrary, PLC became relatively slow its high id="M5"> Further, mass loss results consistent those obtained vitro release. Overall, kinetics PCL/TCH better estimated Zeng model PLA/TCH